Ultrasound delivery of Chinese rhubarb promotes early recovery of gastrointestinal function after gastrectomy: a prospective randomized controlled study

Hengbo Jia, Shaofen Wang, Lujun Shen, J. You, Fan Yang, Masanobu Abe, Yingying Xu, L. Zong
{"title":"Ultrasound delivery of Chinese rhubarb promotes early recovery of gastrointestinal function after gastrectomy: a prospective randomized controlled study","authors":"Hengbo Jia, Shaofen Wang, Lujun Shen, J. You, Fan Yang, Masanobu Abe, Yingying Xu, L. Zong","doi":"10.1097/JBR.0000000000000101","DOIUrl":null,"url":null,"abstract":"Abstract Objective: Chinese rhubarb is a promising Chinese medicine for the promotion of gastrointestinal function. This study was conducted to investigate the safety and efficacy of Chinese rhubarb administered via ultrasound delivery in promoting the early recovery of gastrointestinal function after gastrectomy. Methods: In this prospective randomized controlled study, 100 patients who were scheduled to undergo total or subtotal gastrectomy in Changzhi People's Hospital or Subei People's Hospital from August 2017 to January 2018 were recruited. These patients were randomly assigned into two equal groups before surgery: 50 in the experimental (Chinese rhubarb) group, and 50 in the control (routine nursing) group. After surgery, time to flatus, bowel movement, clear liquid diet, and removal of nasogastric tube were recorded and analyzed. In addition, postoperative pain, postoperative bowel movement-related complications, and postoperative hospital stay duration were also recorded and analyzed. The study was approved by The protocol was approved by the Institutional Review Board of Changzhi People's Hospital and Subei People's Hospital on July 1, 2017 and registered with the Chinese Clinical Trial Registry on December 17, 2018 (registration number: ChiCTR1800020143). Results: Time to flatus (control group 85.68 ± 22.00 hours vs experimental group 73.06 ± 23.42 hours; P = 0.007), bowel movement (5.52 ± 1.56 vs 4.40 ± 1.21 days; P < 0.001), clear liquid diet (6.72 ± 1.16 vs 6.22 ± 1.28 days; P = 0.044), and removal of nasogastric tube (6.30 ± 1.52 vs 5.65 ± 1.58 days; P = 0.044) were significantly shorter in the experimental group compared with the control group, as was the postoperative hospital stay duration (14.30 ± 3.46 vs 12.86 ± 1.36 days; P = 0.006). In addition, better pain relief (P = 0.003) and a lower incidence of postoperative bowel movement-related complications (6 vs 21; P = 0.001) were noted in the experimental group. Conclusion: Ultrasound delivery of Chinese rhubarb is useful to promote the early recovery of gastrointestinal function after gastrectomy.","PeriodicalId":150904,"journal":{"name":"Journal of Bio-X Research","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Bio-X Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/JBR.0000000000000101","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Abstract Objective: Chinese rhubarb is a promising Chinese medicine for the promotion of gastrointestinal function. This study was conducted to investigate the safety and efficacy of Chinese rhubarb administered via ultrasound delivery in promoting the early recovery of gastrointestinal function after gastrectomy. Methods: In this prospective randomized controlled study, 100 patients who were scheduled to undergo total or subtotal gastrectomy in Changzhi People's Hospital or Subei People's Hospital from August 2017 to January 2018 were recruited. These patients were randomly assigned into two equal groups before surgery: 50 in the experimental (Chinese rhubarb) group, and 50 in the control (routine nursing) group. After surgery, time to flatus, bowel movement, clear liquid diet, and removal of nasogastric tube were recorded and analyzed. In addition, postoperative pain, postoperative bowel movement-related complications, and postoperative hospital stay duration were also recorded and analyzed. The study was approved by The protocol was approved by the Institutional Review Board of Changzhi People's Hospital and Subei People's Hospital on July 1, 2017 and registered with the Chinese Clinical Trial Registry on December 17, 2018 (registration number: ChiCTR1800020143). Results: Time to flatus (control group 85.68 ± 22.00 hours vs experimental group 73.06 ± 23.42 hours; P = 0.007), bowel movement (5.52 ± 1.56 vs 4.40 ± 1.21 days; P < 0.001), clear liquid diet (6.72 ± 1.16 vs 6.22 ± 1.28 days; P = 0.044), and removal of nasogastric tube (6.30 ± 1.52 vs 5.65 ± 1.58 days; P = 0.044) were significantly shorter in the experimental group compared with the control group, as was the postoperative hospital stay duration (14.30 ± 3.46 vs 12.86 ± 1.36 days; P = 0.006). In addition, better pain relief (P = 0.003) and a lower incidence of postoperative bowel movement-related complications (6 vs 21; P = 0.001) were noted in the experimental group. Conclusion: Ultrasound delivery of Chinese rhubarb is useful to promote the early recovery of gastrointestinal function after gastrectomy.
超声给药大黄促进胃切除术后胃肠功能的早期恢复:一项前瞻性随机对照研究
【摘要】目的:大黄是一种很有前景的促进胃肠功能的中药。本研究旨在探讨超声给药大黄促进胃切除术后胃肠功能早期恢复的安全性和有效性。方法:本前瞻性随机对照研究招募2017年8月至2018年1月在长治市人民医院或苏北人民医院行胃全切除术或次全切除术的患者100例。术前将患者随机分为两组,实验组(大黄)50例,对照组(常规护理)50例。术后记录并分析排气时间、排便时间、清食时间和鼻胃管拔除时间。此外,还记录和分析了术后疼痛、术后排便相关并发症和术后住院时间。该方案于2017年7月1日由长治市人民医院和苏北人民医院机构审查委员会批准,并于2018年12月17日在中国临床试验注册中心注册(注册号:ChiCTR1800020143)。结果:排气时间(对照组85.68±22.00 h vs实验组73.06±23.42 h);P = 0.007),排便(5.52±1.56 vs 4.40±1.21天;P < 0.001),透明液体日粮(6.72±1.16 vs 6.22±1.28);P = 0.044),鼻胃管拔除(6.30±1.52 vs 5.65±1.58;P = 0.044),术后住院时间(14.30±3.46天vs 12.86±1.36天;p = 0.006)。此外,更好的疼痛缓解(P = 0.003)和更低的术后排便相关并发症发生率(6 vs 21;P = 0.001)。结论:超声给予大黄可促进胃切除术后胃肠功能的早期恢复。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信