Towards a chip-based impedimetric biosensor for gaseous H202 detection

2022 IEEE International Symposium on Olfaction and Electronic Nose (ISOEN) Pub Date : 2022-05-29 DOI:10.1109/ISOEN54820.2022.9789624

F. Vahidpour, Yousef Alghazali, Steffen Thies, G. Hommes, M. Schöning

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Abstract

This paper presents a novel approach for the detection of hydrogen peroxide (H2O2) vapor at low concentrations and room temperature conditions, as these are often used for sterilization in medical industry. Interdigitated electrode structures (IDEs) have been fabricated on glass substrates by means of microfabrication techniques and Ti/Pt evaporation. Impedance spectroscopy is used for impedance measurements of the IDE structures in H2O2 atmosphere, which was provided by a glass bottle containing 20 mL of 35% w/w H2O2 (i.e., free evaporation in a confined space with stable and homogenous temperature). The sensor signal shows changes by varying the H2O2 concentrations inside the gas-tight glass bottle. Selectivity was achieved by means of the enzyme horse radish peroxidase. The detection of low concentrations of H2O2 gas at room temperature and in the aerosol phase is performed in this study for the first time, which paves the path towards on-line monitoring of H2O2 gas in aseptic processing.

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基于芯片的H202气体检测阻抗生物传感器

本文提出了一种在低浓度和室温条件下检测过氧化氢(H2O2)蒸汽的新方法，因为这些通常用于医疗行业的灭菌。采用微加工技术和Ti/Pt蒸发技术在玻璃基板上制备了交叉指状电极结构。阻抗谱用于在H2O2气氛中对IDE结构进行阻抗测量，H2O2气氛由一个玻璃瓶提供，其中含有20 mL 35% w/w的H2O2(即在温度稳定均匀的密闭空间内自由蒸发)。通过改变气密玻璃瓶内的H2O2浓度，传感器信号显示出变化。利用马萝卜过氧化物酶实现了选择性。本研究首次实现了常温下和气溶胶相低浓度H2O2气体的检测，为无菌工艺过程中H2O2气体的在线监测铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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2022 IEEE International Symposium on Olfaction and Electronic Nose (ISOEN)

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