Abnormal Chromosome in Patients with Multiple Myeloma: A Cohor Study in Vietnam

Abstract

Objective: To identify some common chromosomal mutation in patients with Multiple myeloma (MM) at Bach Mai hospital, from June 2016 to June 2021. Methods: We reviewed the cytogenetic results from 363 patients who were diagnosed with MM by IMWG diagnostic criteria 2014 at Bach Mai hospital. Results: Chromosomal abnormalities were detected in 35,3% (128/363) of the patients. Among these results, 128 cases (82,8%) had both numerical and structural chromosome abnormalities. Hyperdiploidy with structural cytogenetic aberrations was the most common finding (42,19%), followed by hypodiploidy with structural aberrations (23,44%). Amplification of the long arm of chromosome 1, loss 13/ del(13q) and abnormality involving 14q32 were the most frequent abnormalities which were observed in 39,84%, 24,2% and 21,9%. The most common numerical abnormalities were gains of chromosomes 9 with 28,57%.