Cytokine and hormone status of women of reproductive age with pulmonary tuberculosis

S. Goponiako
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Abstract

Objective. To study the levels of cytokines (γ-interferon, tumor necrosis factor α (TNF-α)) and hormones (cortisol, prolactin, estradiol, progesterone, testosterone) in blood serum of women of reproductive age with pulmonary tuberculosis (TB).Materials and methods. We studied the serum levels of γ-interferon, tumor necrosis factor α, cortisol, prolactin, estradiol, progesterone, testosterone in women 18-45 years old with newly diagnosed pulmonary TB (n = 47) compared with the same indices in women without TB and with no previous TB (n = 35).Results. Women with pulmonary TB had higher levels of cortisol (cutoff point, 196.1 nmol/L, AUC 0.75, Se 85.1 %, Sp 70.6 %) and prolactin (cutoff point, 486, 1 mEU/L, AUC 0.69, Se 59.6%, Sp 73.5%) and lower serum progesterone levels (cutoff point 3.9 nmol/L, AUC 0.71, Se 73.9%, Sp 64.7%) than women without TB. The study of the levels of γ-interferon and TNF-α showed less diagnostic significance of the parameters, and there was a slight increase in the levels of both cytokines in women with pulmonary TB.Conclusion. Changes in cytokine-hormone status in women with TB can both reflect mechanisms of anti-infective defense and be a consequence of the development of the disease.
育龄妇女肺结核患者的细胞因子和激素水平
目标。目的探讨育龄妇女肺结核(TB)患者血清中细胞因子(γ-干扰素、肿瘤坏死因子α (TNF-α))及激素(皮质醇、催乳素、雌二醇、孕酮、睾酮)水平的变化。材料和方法。我们研究了18-45岁新诊断肺结核妇女(n = 47)的血清γ-干扰素、肿瘤坏死因子α、皮质醇、催乳素、雌二醇、孕酮、睾酮的水平,并将这些指标与未患肺结核和未患肺结核妇女(n = 35)进行了比较。与未患结核病的妇女相比,患有肺结核的妇女皮质醇(临界值,196.1 nmol/L, AUC 0.75, Se 85.1%, Sp 70.6%)和催乳素(临界值,486,1 mEU/L, AUC 0.69, Se 59.6%, Sp 73.5%)水平较高,血清黄体酮水平较低(临界值,3.9 nmol/L, AUC 0.71, Se 73.9%, Sp 64.7%)。研究γ-干扰素和TNF-α水平对诊断意义较低,两种细胞因子水平在女性肺结核患者中均有轻微升高。女性结核病患者细胞因子-激素状态的变化既可以反映抗感染防御机制,也可能是疾病发展的结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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