Genetic analysis of mammalian cell differentiation.

Abstract

CONTENTS IN TRODUCTI ON......... .... ......... 69 HIST ORICAL PERSPECTIVE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 70 THE HYBRID CE LL PHEN O TyPES 72 Extinction and Reexpression 72 Activation and Gene Dosage Effects 74 Properties of Intratypic Hybrids 77 GENETIC BASIS OF EXTINCTI ON . . . . . . . . . . . . . . . . . . . . . . ... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 77 Properties of Microcell Hybrids 78 Extinction Phenotypes of Microcell Hybrids 78 Properties of Tissue-Specific Extinguisher Loci , . . . . . . . . . . . . . . . . . . . . . . 80 MECHANISMS OF EXTINCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 82 Pituitary Cell Hybrids .... 82 Myeloma Hybrids 83 Hepatoma Hybrids 84 CONCLUSIONS AND PROSPECTS 86