Design of PDMS membrane for CTC separation

Abstract

Circulating tumorcells(CTC) are the primary tumor cells which contains the key information about the cancer. These CTCs can be separated from the peripheral blood in microfluidics, where a PDMS(polydimethylsiloxane) membrane can be designed for CTC detection. The PDMS membrane is designed with cylindrical pores for the detection of Circulating TumorCells(CTC) from the peripheral blood samples. The membrane consisting of cylindrical pores of size 9μm and the distance between the pores are designed to be (15μm) are simulated and analysed for the separation of CTCs.