Effect of The Recommended Dose of Dimethoate and Its Double on The Embryos and Testicular Tissues in Male Mice

Abstract

Exposure to pesticides negatively have associated with many public health hazards infecting humans as infertility, therefore, the objective of this study was to investigate the effect of dimethoate on testicular cytoarchitecture of treated mice and on the embryos. Albino mice were divided into three groups of 9 each: the first group served as control and was given distilled water orally, whereas the second and third groups were given dimethoate at doses (0.1 and 0.2 mL dimethoate/100 mL distilled water) respectively for 20 days. At the end of the treatment, six mice from each group were weighed and sacrificed, the testis and epididymis weights were recorded, and histopathological lesions of tests were carried out. The obtained results revealed that dimethoate caused a decrease in the body and epididymis weights. Furthermore, dimethoate led to a significant decrease in the number of dead embryos and their weights. Histopathological examination demonstrated that this pesticide caused marked alterations in the microstructure of testicular tissues appeared as vacuoles, disorganization of the germinal epithelium, and degenerative changes in some seminiferous tubules as well as its effect on the embryos, therefore, more efforts should be conducted to protect our environment and health from these detrimental compounds and the search for safe methods for insect control.