Gecikmiş Kas Ağrısı ve Oluşum Mekanizmaları: Oksidatif Stres ile İlişkisi

Abstract

Delayed onset muscle soreness (DOMS) was defined for the first time by Hough in 1902. Hough stated that DOMS is a kind of disturbance felt in muscles after 8-10 hours following the exercise performed for the first time in untrained people and emphasized that this could not only be associated with fatigue. Thereon, the DOMS of interest and number of studies on the subjects increased. However, the formation mechanism of DOMS is not disclosed in full. It is well known that oxidative stress increases after the muscle contractile activities and induces muscle damage. It is considered to be a connection between the muscle damage induced by oxidative stress and DOMS. But it is not clear whether the increased oxidative stress effect DOMS formation or not. Limited number of studies focused on this topic showed that oxidative stress was related to DOMS. Hence, this review is limited with the studies tried to explain possible mechanism and examined the relationship between oxidative stress and DOMS. For this, DOMS was defined and formation mechanisms of DOMS were explained. After the definition of oxidative stress the research examined the relationship between DOMS and oxidative stress were presented. It has been demonstrated that oxidative stress damage causes muscle damage and this is the most probable mechanism to explain the DOMS in cellular level. The studies showed that free radicals act as intracellular signaling molecules and stimulate the molecules that provide muscle adaptation to exercise. It has been reported that the DOMS formation is decreased after eccentric activities performed repeatedly. Additionally, it has been shown that the use of antioxidant supplementation decreases DOMS and delays the DOMS formation.