Arterial stiffness and metabolic syndrome indices in renal transplantation patients

Abstract

Orhan Guliyev, Elgun Heziyev, Shelale Ismayilova, Arzu Ibishova, Mehman AgayevAzerbaijan Medical Unixersity, Baku, Azerbaijan PuRPOSE ANd RElEvANCE: Although renal transplantation improves survival, cardiovascular morbidity and mortality still remain as a significant problem compared with nonrenal populations. In end stage renal disease metabolic cardiovascular risk factors such as hypertension, hyperuricemia, obesity and diabetes mellitus have been confirmed to be positively correlated with arterial stiffness. Arterial stiffness is an important characteristic of the arterial wall and can be assessed noninvasively by the measurement of carotid-femoral pulse wave velocity (PWv). The aim of this study is to evaluate the risk factors for arterial stiffness in kidney transplant recipients�PARTICIPANTS: One hundred and forty nine kidney transplant recipients from our renal transplant outpatient clinic were enrolled into the study.METHOdS ANd ANAlySIS: All patients were evaluated for their standard clinical (age, gender, duration of hemodialysis, post-transplant time), biochemical parameters. Anthropometric and body composition analyses were performed for all patients. Body compositions were analyzed by using the Body Composition Analyzer (Tanita BC- 420MA). PWv was determined from pressure tracing over carotid and femoral arteries using the SphygmoCor system.RESulTS: Patients were divided into two groups according to PWv levels. The frequency of patients with PWv ≥ 7 m/s was higher in patients with new onset diabetes (55.9%), hyperuricemia (uric acid level > 7 mg/dl) (p:0.029, 0.05). Highercarotid-femoral PWv was significantly related with systolic (p:0.003) and diastolic blood pressure (p:0.002),