Blood Urea Nitrogen to Albumin Ratio is a Predictor of Mortality among Hospitalized Geriatric Patients with COVID-19.

*. Khalid E. Elsorady et al.,
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Abstract

: Aim : This study aims to determine predictors of mortality among hospitalized geriatric patients with COVID-19 with a particular concern about the predictive value of blood urea nitrogen to albumin ratio (BAR). Methods : A retrospective cohort study included 114 geriatric patients (aged ≥ 60 years) admitted to a geriatrics hospital for isolation. A review of the medical files of participants was conducted to extract data regarding age, sex, comorbidities, clinical manifestations of COVID-19 and laboratory data including haematology, biochemistry and inflammatory markers on admission. BAR and Charlson comorbidity index (CCI) were calculated. The primary outcome was in-hospital mortality. Appropriate statistical analyses were operated. RESULTS : 59 (51.8%) patients died at the hospital. Comorbidities associated with mortality included diabetes mellitus, old stroke, hypertension, and cardiac disease besides higher CCI. Reporting of fever, fatigue, sore throat and delirium /altered mental status were also associated with mortality. Significant biomarkers included lower hemoglobin and serum albumin, higher total leukocyte count, serum creatinine, blood urea nitrogen, lactate dehydrogenase, D-dimer, c-reactive protein (CRP) and BAR. BAR at a cutoff of 12.92 mg/gm had the best predictive performance for mortality. Serum BAR > 12.92 mg/gm, albumin < 3.05 g/dl and CRP > 108 mg/l were independent predictors of in-hospital mortality CONCLUSION : Serum BAR > 12.92 mg/gm, albumin < 3.05 g/dl and CRP > 108 mg/l are independent predictors of mortality among hospitalized geriatric patients with COVID-19. BAR is a convenient biomarker and has the best predictive performance to early pick up COVID-19 geriatric patients at high risk of mortality.
血液尿素氮与白蛋白比是住院老年COVID-19患者死亡率的预测因子
目的:本研究旨在确定COVID-19住院老年患者死亡率的预测因素,特别关注血液尿素氮与白蛋白比(BAR)的预测价值。方法:回顾性队列研究纳入114例在老年医院接受隔离的老年患者(年龄≥60岁)。回顾参与者的医疗档案,提取年龄、性别、合并症、COVID-19临床表现以及入院时血液学、生物化学和炎症标志物等实验室数据。计算BAR和Charlson共病指数(CCI)。主要终点是住院死亡率。进行了适当的统计分析。结果:59例(51.8%)患者在医院死亡。与死亡率相关的合并症包括糖尿病、老年卒中、高血压和心脏病,以及较高的CCI。报告发烧、疲劳、喉咙痛和谵妄/精神状态改变也与死亡率有关。显著的生物标志物包括血红蛋白和血清白蛋白降低,白细胞总数、血清肌酐、血尿素氮、乳酸脱氢酶、d -二聚体、c反应蛋白(CRP)和BAR升高。以12.92 mg/gm为临界值的BAR对死亡率的预测效果最好。结论:血清BAR - > 12.92 mg/gm、白蛋白< 3.05 g/dl、CRP - > 108 mg/l是住院老年COVID-19患者死亡率的独立预测因子。BAR是一种便捷的生物标志物,对早期发现的高死亡风险老年患者具有最佳的预测效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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