{"title":"Blood Urea Nitrogen to Albumin Ratio is a Predictor of Mortality among Hospitalized Geriatric Patients with COVID-19.","authors":"*. Khalid E. Elsorady et al.,","doi":"10.21608/ejgg.2022.267997","DOIUrl":null,"url":null,"abstract":": Aim : This study aims to determine predictors of mortality among hospitalized geriatric patients with COVID-19 with a particular concern about the predictive value of blood urea nitrogen to albumin ratio (BAR). Methods : A retrospective cohort study included 114 geriatric patients (aged ≥ 60 years) admitted to a geriatrics hospital for isolation. A review of the medical files of participants was conducted to extract data regarding age, sex, comorbidities, clinical manifestations of COVID-19 and laboratory data including haematology, biochemistry and inflammatory markers on admission. BAR and Charlson comorbidity index (CCI) were calculated. The primary outcome was in-hospital mortality. Appropriate statistical analyses were operated. RESULTS : 59 (51.8%) patients died at the hospital. Comorbidities associated with mortality included diabetes mellitus, old stroke, hypertension, and cardiac disease besides higher CCI. Reporting of fever, fatigue, sore throat and delirium /altered mental status were also associated with mortality. Significant biomarkers included lower hemoglobin and serum albumin, higher total leukocyte count, serum creatinine, blood urea nitrogen, lactate dehydrogenase, D-dimer, c-reactive protein (CRP) and BAR. BAR at a cutoff of 12.92 mg/gm had the best predictive performance for mortality. Serum BAR > 12.92 mg/gm, albumin < 3.05 g/dl and CRP > 108 mg/l were independent predictors of in-hospital mortality CONCLUSION : Serum BAR > 12.92 mg/gm, albumin < 3.05 g/dl and CRP > 108 mg/l are independent predictors of mortality among hospitalized geriatric patients with COVID-19. BAR is a convenient biomarker and has the best predictive performance to early pick up COVID-19 geriatric patients at high risk of mortality.","PeriodicalId":405276,"journal":{"name":"The Egyptian Journal of Geriatrics and Gerontology","volume":"21 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Egyptian Journal of Geriatrics and Gerontology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21608/ejgg.2022.267997","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
: Aim : This study aims to determine predictors of mortality among hospitalized geriatric patients with COVID-19 with a particular concern about the predictive value of blood urea nitrogen to albumin ratio (BAR). Methods : A retrospective cohort study included 114 geriatric patients (aged ≥ 60 years) admitted to a geriatrics hospital for isolation. A review of the medical files of participants was conducted to extract data regarding age, sex, comorbidities, clinical manifestations of COVID-19 and laboratory data including haematology, biochemistry and inflammatory markers on admission. BAR and Charlson comorbidity index (CCI) were calculated. The primary outcome was in-hospital mortality. Appropriate statistical analyses were operated. RESULTS : 59 (51.8%) patients died at the hospital. Comorbidities associated with mortality included diabetes mellitus, old stroke, hypertension, and cardiac disease besides higher CCI. Reporting of fever, fatigue, sore throat and delirium /altered mental status were also associated with mortality. Significant biomarkers included lower hemoglobin and serum albumin, higher total leukocyte count, serum creatinine, blood urea nitrogen, lactate dehydrogenase, D-dimer, c-reactive protein (CRP) and BAR. BAR at a cutoff of 12.92 mg/gm had the best predictive performance for mortality. Serum BAR > 12.92 mg/gm, albumin < 3.05 g/dl and CRP > 108 mg/l were independent predictors of in-hospital mortality CONCLUSION : Serum BAR > 12.92 mg/gm, albumin < 3.05 g/dl and CRP > 108 mg/l are independent predictors of mortality among hospitalized geriatric patients with COVID-19. BAR is a convenient biomarker and has the best predictive performance to early pick up COVID-19 geriatric patients at high risk of mortality.