[Morphological of biological effects of progestagens].

Abstract

During their clinical studies on human endometric tissue in normal and pathologic condition authors attempt to determine morphologic changes occurring to the effect of progestagens. Klt is established that progestagens cause typical morphologic changes which are manifested in regression of endometrium on varying scale. The most striking effect is exerted on mitochondria among respective cell organelles; it means the damage of these structures. Decrease of enzymatic processes linked to mitochondrea, caused by effect of progestagens, presumably inhibits cell proliferation. Inhibition of cellular oxidation in pathologic conditions, like in endometric hyperplasia and in highly differentiated cases of endometric cancer, can be of therapeutic effect. Their studies provide opportunity to interpretation of morphologic changes performed in hormone dependent tissues and to better understanding of its role in carcinogenesis of sexual hormones.