{"title":"Transitory models of experimentally induced intraocular pressure changes in the rabbit","authors":"C. Hariton, D. Marce, C. Debon","doi":"10.1016/0160-5402(90)90019-H","DOIUrl":null,"url":null,"abstract":"<div><p>The purpose of this study was to evaluate the relationship between inducer dosage, animal weight, and kinetics in intraocular pressure (IOP) changes in three transitory-induced models for antiglaucoma drugs screening: oral water-loading, 5% glucose intravenous administration, and 20% NaCl infusion. For these models, a dose-dependent elevation of IOP was observed in three weight groups of rabbits (1, 2.2, and 3.8 kg). Dose-effect relationships were established, considering for each weight group two relevant parameters: maximal IOP changes and areas under or upper the kinetic curves of IOP changes. Among the three models studied, our results led us to consider water-loading as a weight-independent model, allowing us to compare results obtained by this model in New Zealand rabbits with different ages (40–150 days) or weights (0.9–3.8 kg).</p></div>","PeriodicalId":16819,"journal":{"name":"Journal of pharmacological methods","volume":"24 2","pages":"Pages 79-88"},"PeriodicalIF":0.0000,"publicationDate":"1990-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0160-5402(90)90019-H","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of pharmacological methods","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/016054029090019H","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5
Abstract
The purpose of this study was to evaluate the relationship between inducer dosage, animal weight, and kinetics in intraocular pressure (IOP) changes in three transitory-induced models for antiglaucoma drugs screening: oral water-loading, 5% glucose intravenous administration, and 20% NaCl infusion. For these models, a dose-dependent elevation of IOP was observed in three weight groups of rabbits (1, 2.2, and 3.8 kg). Dose-effect relationships were established, considering for each weight group two relevant parameters: maximal IOP changes and areas under or upper the kinetic curves of IOP changes. Among the three models studied, our results led us to consider water-loading as a weight-independent model, allowing us to compare results obtained by this model in New Zealand rabbits with different ages (40–150 days) or weights (0.9–3.8 kg).
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