Dynamic study of concentrations of inflammatory and anti-inflammatory interleukins in patients with neck injuries

Abstract

The cytokine status was studied in 64 patients with neck injuries and damage to internal structures. Severe trauma causes damage to the protective barriers of the organism and activates immunological reaction. Among substances secreted during this process pro-inflammatory cytokines are of high importance. It is shown, that monitoring of cytokine status (IL-6, IL-8, IL-10, TNFα) in the acute period of trauma had been having important clinical, prognostic and diagnostic values. A dynamic study of the concentrations of pro-inflammatory and anti-inflammatory interleukins during the first ten days in patients, together with clinical data, made it possible to change the routine treatment tactics and optimize the terms and scope of surgical care. The TNFα is a reliable indicator of a developing infectious complication and takes a chance to change antibacterial or anti-inflammatory therapy and improve effects of therapy.