[8-MOP serum level profile following administration of Geroxalen to patients with psoriasis and a control group].

Abstract

Unlabelled: After 8-MOP application (Geroxalen) the mean serum levels with 11 single values over 8 hours from 21 psoriatics with squamous infiltrative plaques do not differ from serum level curves of 46 healthy volunteers (Psoriatics: maximum plasma level cmax 189 nm 8 MOP/ml serum at the time tmax 1,2h; area under the curve AUC0-8 284 ng.ml-1.h.

Control group: cmax 193 ng 8 MOP/ml serum; tmax 0.9h; AUC0-8 290 ng.ml-1.h). A malabsorption of 8-MOP in psoriatic patients could not be found in our study, although this is described for fat among other.