Restrictive Versus Liberal Fluid Bolus Therapy in Pediatric Septic Shock: Should It Be Debated

Abstract

To date, sepsis has contributed significantly to the child mortality rate, which is around 8.9% in developed countries to 14.2% in developing countries [1-3]. The most common cause of death (23.1-34.6%) was refractory shock [2-4], of which most occured in the first 3 days [5]. An additional hour of persistent shock was associated with >2-fold increased odds of mortality [6]. This shows that early treatment of septic shock is one of the keys to reduce sepsis mortality.