Impedance Spectroscopy based on The Cell Trajectory and New Strategy to Enhance The Accuracy of The Detection in The Microfluidic System

Abstract

Micro electric impedance spectroscopy (µEIS), are very tiny devices that use fluid as a working medium in conjunction with biological cells to extract different electrical parameters. Many advantages can be provided by using these tiny microfluidic devices, such as portability, disposable, and high accuracy. Dielectric parameters of biological cells are one of the interesting parameters that can be extracted using µEIS. This computational study represents the modification for both systems the parallel facing electrodes and the Coplanar electrodes using two main features the number of electrodes and the sequence of the excitation signal. The main target of the study is to show the sensitivity of each configuration related to the cell positioning and how can overcome the cell positioning effect using a new excitation signal distribution method and the number of electrodes. The proposed design and simulation results enhance the response of the microfluidic system.