Metabotropic Receptors 4 and the Immune Responses

Abstract

Neurotransmitters (NTs) have recently received increasing appreciation as important immune modulators. The immune cells express receptors for many classes of NTs and the communication between NTs and their receptors establish neuro-immune interactions for regulating effective immune response in both central nervous system (CNS) and peripheral tissues. Metabotropic Glutamate Receptor 4 (mGluR4) is expressed at high level in CNS and plays a role in various physiological and pathophysiological processes in CNS. Recently, mGluR4 has been reported to be expressed on immune cells and have an impact on regulating the immune system. This chapter summarized the works associated with the immunogenic function of mGluR4 and its potential underlying mechanisms.