Magnetic Phagocyte Quantification Framework for Point-of-Care Diagnostics

Abstract

A novel framework to quantify the phagocytic ability of a septic patient’s immune system is proposed for Point-of-Care (PoC) diagnostic applications. The design utilizes biofunctionalized ferromagnetic particles to affect the flow rate of phagocytes passing through an impedimetric sensor. The electrical, microfluidic, and magnetic subsystems of the design are analyzed. Preliminary simulation and experimental results demonstrate the feasibility of the system. Additionally, fabrication procedures and system calibrations are discussed, and a control assay is proposed.