PSYCHO-ONCOLOGY. CASE PRESENTATION

A. Pâslaru, A. Fătu, Alexandru Nechifor, L. Rebegea, D. Iliescu, A. Ciubară
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Abstract

Increased survival of oncology patients brings to attention new aspects of adverse effects due to antineoplastic treatment. Psychiatric disorders, cardiovascular disorders as well as the progressive incidence of multiple primary neoplasia are some of the most common side effects. Aim: Care of the oncology patient undergoes an important period of change, from the management of tumor disease to the multidisciplinary approach, centered on improving the quality of life. Method: We present the case of a 75-year-old patient, whose personal pathological history reveals the presence of a diagnosis of left testicular seminoma, in 1978, for which he received radiochemical therapy. An oncological patient under long-term medical supervision for several decades is diagnosed in November 2017 with urothelial carcinoma, infiltrative, invasive in his own muscle patch, pT2NxMx. Approximately 40 years later, the second neoplastic site, the malignant bladder tumor, appears. Facing this diagnosis, the patient becomes anxious, anticipates catastrophic consequences, isolates himself. The family and friends support is essential in these moments, the patient tries cognitive-behavioral psychotherapy, as well as various relaxation techniques, which have positive results for the patient attitude towards the disease. He admits, to complete staging, to follow the recommendations of the oncologist, perform proton emission tomography, which detects the presence of two lesions on the right lung. In January 2018, the surgical intervention is done by straight thoracotomy, atypical upper lobe resection and inferior lobectomy is performed. The histopathological and immunohistochemical results describe the presence of the third primary adenocarcinoma neoplasia. The initial emotional reaction is one of anger, denial, followed by demoralization, easy crying, sadness. The patient is examined by the psychiatrist, thus receiving the diagnosis of a severe depressive episode without psychotic symptoms. He follows an anxiolytic, antidepressant, sedative treatment but continues also the cognitive-behavioral therapy. The patient shows good compliance with psychopharmacological treatment and accepts adjuvant chemotherapy courses, which are well tolerated. Throughout the antineoplastic therapy, there was a close collaboration between the psychiatrist and the oncologist, to avoid drug interactions that could have led to interruption of the treatment. Under the oncology supervision, the patient receives another bad news, in September 2018, the fourth neoplastic localization, the prostatic adenocarcinoma pT2bN0M0, is discovered. In this case, in the presence of the combination of synchronous and methacrone tumors, the patient's psyche is deeply affected, continuing the psychopharmacological treatment. Conclusions: Psychiatric disorders are common among oncological patients, and they may suffer serious impairments in quality of life and treatment compliance, psycho-oncological collaboration being indispensable for the success of antineoplastic treatment.
PSYCHO-ONCOLOGY。案例展示
肿瘤患者生存率的提高引起了人们对抗肿瘤治疗不良反应的新关注。精神疾病、心血管疾病以及多发性原发性肿瘤的逐渐发生是一些最常见的副作用。目的:肿瘤患者的护理经历了一个重要的转变时期,从肿瘤疾病的管理到以提高生活质量为中心的多学科方法。方法:我们提出的情况下,75岁的病人,其个人病理史显示左睾丸精原细胞瘤的诊断存在,在1978年,他接受了放化疗。一名长期医疗监护数十年的肿瘤患者于2017年11月被诊断为尿路上皮癌,浸润性,侵袭性,其自身的肌肉斑块pT2NxMx。大约40年后,第二个肿瘤部位,恶性膀胱肿瘤出现。面对这种诊断,病人变得焦虑,预期灾难性的后果,孤立自己。在这些时刻,家人和朋友的支持是必不可少的,患者尝试认知行为心理治疗,以及各种放松技巧,这些都对患者对疾病的态度产生了积极的影响。他承认,为了完成分期,按照肿瘤学家的建议,他进行了质子发射断层扫描,这可以检测到右肺上两个病变的存在。2018年1月,手术干预行直开胸、非典型上肺叶切除、下肺叶切除术。组织病理学和免疫组织化学结果描述了第三原发性腺癌肿瘤的存在。最初的情绪反应是愤怒,否认,随后是士气低落,容易哭泣,悲伤。精神科医生对患者进行检查,诊断为严重抑郁发作,但无精神病症状。他接受了抗焦虑药、抗抑郁药和镇静剂的治疗,但也继续接受认知行为疗法。患者心理药理学治疗依从性好,接受辅助化疗疗程,耐受性良好。在整个抗肿瘤治疗过程中,精神科医生和肿瘤科医生密切合作,以避免可能导致治疗中断的药物相互作用。在肿瘤学监督下,患者又收到了一个坏消息,2018年9月,第4例肿瘤定位,前列腺腺癌pT2bN0M0被发现。在这种情况下,在同时存在和美沙酮肿瘤的情况下,患者的精神受到了深刻的影响,继续进行精神药物治疗。结论:肿瘤患者普遍存在精神障碍,生活质量和治疗依从性受到严重影响,抗肿瘤治疗的成功离不开心理与肿瘤的合作。
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