Prevalence of other autoimmune diseases in children and adolescents with type 1 diabetes mellitus

Residência Pediátrica Pub Date : 1900-01-01 DOI:10.25060/residpediatr-2023.v13n2-694

F. Ribas, Ricardo Ribeiro, M. Cat, S. França

{"title":"Prevalence of other autoimmune diseases in children and adolescents with type 1 diabetes mellitus","authors":"F. Ribas, Ricardo Ribeiro, M. Cat, S. França","doi":"10.25060/residpediatr-2023.v13n2-694","DOIUrl":null,"url":null,"abstract":"OBJECTIVE: To evaluate the prevalence of autoimmune markers associated with beta-pancreatic cells, autoimmune thyroid diseases and celiac disease through research of anti-glutamic acid decarboxylase antibodies (GADA), antiislet cell antibodies (ICA), anti-insulin antibodies (IAA), anti-tyrosine phosphatase (IA-2A), anti-transglutaminase antibodies (anti-tTG), anti-endomysium anti-transglutaminase antibodies (EMA ), immunoglobulin A (IgA), thyroperoxidase antibodies (anti-TPO) and thyroglobulin antibodies (anti-TG), in addition to related hormonal measurements in children and adolescents with type 1 diabetes mellitus. METHODS: Observational, longitudinal study, with retrospective data collection by reviewing the medical records of 92 children and adolescents, diagnosed with DM1 between January 2014 and December 2016, seen at a Pediatric Endocrinology service of a tertiary hospital in Curitiba- PR. RESULTS: At the diagnosis of DM1, the prevalence of anti-GAD antibody positivity was 69.6% (n = 79), ICA 42.9% (n = 70), IAA 32.8% (n = 64), IA2 of 60.6% (n = 33). Positivity for markers of other associated autoimmune diseases was 27.4%, EMA 6.0% (n = 50), anti t-TG IgA 12.5% (n = 8), anti-TPO 13, 1% (n = 84) and 22.9% anti-TG (n = 83). Autoimmune thyroid diseases were the most frequently found comorbidity at diagnosis (22.1%). Among patients with positivity for antithyroid antibodies, 19% developed clinical hypothyroidism. CONCLUSIONS: Patients with DM1 have a high prevalence of autoimmunity. The importance of screening for such diseases to diagnosis and clinical follow-up is reinforced, in order to assist in predicting the development of associated diseases and their complications, as well as providing adequate treatment.","PeriodicalId":338092,"journal":{"name":"Residência Pediátrica","volume":"36 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Residência Pediátrica","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.25060/residpediatr-2023.v13n2-694","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

OBJECTIVE: To evaluate the prevalence of autoimmune markers associated with beta-pancreatic cells, autoimmune thyroid diseases and celiac disease through research of anti-glutamic acid decarboxylase antibodies (GADA), antiislet cell antibodies (ICA), anti-insulin antibodies (IAA), anti-tyrosine phosphatase (IA-2A), anti-transglutaminase antibodies (anti-tTG), anti-endomysium anti-transglutaminase antibodies (EMA ), immunoglobulin A (IgA), thyroperoxidase antibodies (anti-TPO) and thyroglobulin antibodies (anti-TG), in addition to related hormonal measurements in children and adolescents with type 1 diabetes mellitus. METHODS: Observational, longitudinal study, with retrospective data collection by reviewing the medical records of 92 children and adolescents, diagnosed with DM1 between January 2014 and December 2016, seen at a Pediatric Endocrinology service of a tertiary hospital in Curitiba- PR. RESULTS: At the diagnosis of DM1, the prevalence of anti-GAD antibody positivity was 69.6% (n = 79), ICA 42.9% (n = 70), IAA 32.8% (n = 64), IA2 of 60.6% (n = 33). Positivity for markers of other associated autoimmune diseases was 27.4%, EMA 6.0% (n = 50), anti t-TG IgA 12.5% (n = 8), anti-TPO 13, 1% (n = 84) and 22.9% anti-TG (n = 83). Autoimmune thyroid diseases were the most frequently found comorbidity at diagnosis (22.1%). Among patients with positivity for antithyroid antibodies, 19% developed clinical hypothyroidism. CONCLUSIONS: Patients with DM1 have a high prevalence of autoimmunity. The importance of screening for such diseases to diagnosis and clinical follow-up is reinforced, in order to assist in predicting the development of associated diseases and their complications, as well as providing adequate treatment.

查看原文本刊更多论文

儿童和青少年1型糖尿病患者其他自身免疫性疾病的患病率

摘要目的:通过抗谷氨酸脱羧酶抗体(GADA)、抗胰岛细胞抗体(ICA)、抗胰岛素抗体(IAA)、抗酪氨酸磷酸酶(IA-2A)、抗谷氨酰胺转胺酶抗体(anti-tTG)、抗肌内膜抗谷氨酰胺转胺酶抗体(EMA)、免疫球蛋白A (IgA)的研究，评价与β -胰腺细胞、自身免疫性甲状腺疾病和乳糜泻相关的自身免疫标志物的患病率。甲状腺过氧化物酶抗体(抗tpo)和甲状腺球蛋白抗体(抗tg)，以及1型糖尿病儿童和青少年的相关激素测量。方法:对2014年1月至2016年12月在库里提巴- PR某三级医院儿科内分泌科就诊的92例确诊为DM1的儿童和青少年进行观察性、纵向研究，回顾性收集资料。结果:诊断为DM1时，抗gad抗体阳性率为69.6% (n = 79)， ICA为42.9% (n = 70)， IAA为32.8% (n = 64)， IA2为60.6% (n = 33)。其他相关自身免疫性疾病标志物阳性率为27.4%，EMA为6.0% (n = 50)，抗t-TG IgA为12.5% (n = 8)，抗tpo为13.1% (n = 84)，抗tg为22.9% (n = 83)。自身免疫性甲状腺疾病是诊断时最常见的合并症(22.1%)。在抗甲状腺抗体阳性的患者中，19%发生临床甲状腺功能减退。结论:DM1患者具有较高的自身免疫患病率。为了帮助预测相关疾病及其并发症的发展，并提供适当的治疗，加强了对这类疾病的筛查对诊断和临床随访的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Residência Pediátrica

自引率

0.00%

发文量