Wound healing effects of bee venom on adipose tissue derived mesenchymal stem cells

Abstract

The objective of this study is to determine the effects of bee venom on the proliferation capacity of mesenchymal stem cells and wound healing. For this purpose, mesenchymal stem cells were isolated from canine adipose tissue and bee venom samples were collected from Apis mellifera anatoliaca in Muğla provinces. Cell viability test was performed on mesenchymal stem cells exposed to different concentrations (50 ppm, 25 ppm, 12,5 ppm, 6,25 ppm, 3,125 ppm, and 1,56 ppm) of bee venom. And wound healing assay was performed on cells treated with the same doses and imaged every two hours for 16 hours. Even while we have a better understanding of the mechanisms of action of bee venom components, there are still many unsolved questions on the subject.