Papel de la imagen de movimiento incoherente intravóxel (IVIM) en la evaluación de la respuesta del carcinoma hepatocelular después de la quimioembolización transarterial (TACE): un estudio prospectivo
IF 1.1 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
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引用次数: 0
Abstract
Introduction
Response evaluation of hepatocellular carcinoma (HCC) currently is based on arterial phase enhancement which doesn’t take into microstructural changes in the tumor after trans-arterial chemoembolization (TACE).
Aim
This prospective study was conducted to assess the feasibility and efficacy of intravoxel incoherent motion imaging (IVIM) in response evaluation of HCC after TACE.
39 cirrhotic patients with 48 HCC underwent MR imaging 1 week within and 6 weeks after TACE. IVIM parameters like Dslow (true diffusion), Dfast (pseudodiffusion), perfusion fraction and ADC were measured prior to and postTACE. The pre and postTACE values in LR-TR (LIRADS-treatment response) nonviable and viable lesions were compared using paired t-tests. ROC curve analysis was done to calculate sensitivity and specificity and propose cut-off values.
Result
Non-viable lesions showed a significant increase in Dslow (1.208 ± 0.581 vs. 1.560 ± 0.494, p-value –0.0207) and ADC (1.37 ± 0.53 vs. 1.65 ± 0.4287, p-value 0.016) after TACE. There was also significant decrease in Dfast (33.7 ± 10.4 vs. 23.75 ± 12.13, p-value 0.0005) and f (19.92 ± 10.54 vs. 12.9 ± 10.41, p-value 0.012) values after TACE in non-viable lesions compared to viable lesions. The change in true diffusion had the highest AUC (0.741) among IVIM parameters with greater than 0.075 increase between preTACE and postTACE values having a sensitivity and specificity of 81.8% and 60% respectively for complete response.
Conclusion
IVIM imaging is feasible to assess the response in HCC after TACE. True diffusion is more sensitive and specific than apparent diffusion in evaluating the response.
RADIOLOGIARADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
1.60
自引率
7.70%
发文量
105
审稿时长
52 days
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