Clinical Study of the Protective Effect of Exogenous Creatine Phosphate on Ischemic Myocardium during Open Heart Surgery

The Journal of ExtraCorporeal Technology Pub Date : 1999-03-01 DOI:10.1051/ject/1999311012

P. Dong, Jing Yang, Yu-ying Pan, Y. Guan, M. He

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引用次数: 1

Abstract

This study was designed to evaluate the myocardial protective effect of exogenous creatine phosphate (CP) added to cardioplegic solution for use in open heart surgery. Ninety-eight patients were divided into a control group (n = 44) and a CP group (n =54). The spontaneous recovery rate of heart beat after aortic declamping was recorded and changes of serum enzymes including CPK, LDH, CPK-MB, HBDH, and AST were evaluated. The ultrastructural alterations of the myocardial tissue were observed in 4 patients (2 cases from each group) who had cardiac valve replacement. The spontaneous recovery rate of heart beat in the CP group was significantly higher than the control group (39/54 versus 22/44 ), and the peak values of leakage of serum enzymes of the control group appeared earlier and receded later than those of the CP group. Electron microscope examination revealed better preservation of the ultrastructures of the myocardial tissue in the CP group than that of the control group. This data indicates that exogenous creatine phosphate added to the cardioplegic solution offers a better protective effect on the ischemic myocardium during open heart surgery.

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外源性磷酸肌酸对心脏直视手术中缺血心肌保护作用的临床研究

本研究旨在评价外源性磷酸肌酸(CP)加入心脏直视手术停搏液中对心肌的保护作用。98例患者分为对照组(n = 44)和CP组(n =54)。记录主动脉瓣置换术后心跳自发恢复率，评价血清酶(CPK、LDH、CPK- mb、HBDH、AST)的变化。观察4例(每组2例)行心脏瓣膜置换术后心肌组织超微结构改变。CP组心跳自发恢复率显著高于对照组(39/54比22/44)，对照组血清酶渗漏峰值出现早、消退晚于CP组。电镜观察显示，CP组心肌组织超微结构保存较对照组好。这一数据表明，外源性磷酸肌酸添加到心脏停搏液中，对心脏直视手术中缺血心肌具有较好的保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Journal of ExtraCorporeal Technology

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