Correlation Between Frozen Section and Definitive Diagnosis in High-Risk Endometrial Carcinoma: Retrospective Analysis

Abstract

examination in high-risk endometrial carcinoma cases. Material and Methods: In this retrospective study, the pathology archives of our center were evaluated and 90 high risk endometrial carcinoma cases that were examined intraoperatively, between 2005-2017 were analyzed. The following criteria were used to identify high-risk endometrial carcinoma cases: Grade 3 endometrioid carcinomas with lymphovascular invasion and/or myometrial invasion of more than half, tumors of stage 2, 3, 4 and non-endometrioid endometrial carcinoma. Results: Histopathological subtyping was accurate in 52 of the 57 cases of endometrioid carcinoma, 3 of the 20 cases of serous carcinoma and 1 of the 4 cases of clear cell carcinoma. None of the patients diagnosed with mixed carcinoma were accurately diagnosed in frozen section. When results of intraoperative and permenant evaluations were compared; 74.4% of the cases were compatible for histopathological subtype, 76.7% for grade, and 77.7% for myometrial invasion. Conclusion: In patients with high-risk endometrial carcinoma without a preoperative diagnosis, intraoperative evaluation is essential for determining prognostic parameters and performing surgical staging intraoperatively. Despite the careful evaluation of pathologists, the error rate is high in in- traoperative evaluation of high-risk endometrial carcinomas. In order to minimize the error rate, both gross and microscopical assessment should be performed with utmost care.