SCREENING OF ANTIOXIDANT AND ANTIMICROBIAL POTENTIAL OF HAWTHORN (CREATAGUS MONOGYNA) FRUIT AND LEAVES EXTRACTS

Abstract

In the present study, water and methanol extracts of hawthorn ( Creatagus monogyna ) were studied for antioxidant and antimicrobial properties. The antioxidant properties of fruits and leaves were evaluated by determining DPPH radical scavenging activity. The water and methanol extracts of both  fruits and leaves have antioxidant  potential, ranging from 3.7 %to 44 %. Antimicrobial activities of above extracts were also tested against clinical isolates of human pathogenic strains belonging to 4 bacteria, Enterobacter aerogenes, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and 3 yeast species, Candida albicans, Candida glabrata and Candida parapisilosis, by disc-diffusion method. The minimal inhibition concentration (MIC) value of each active extracts was also determined. The most effective antibacterial activity was expressed by methanol extract of hawthorn leaves against Gram-positive bacteria Staphylococcus aureus with 12mm inhibition zone and 0.625 mg/ml MIC value. None of the  extracts have antifungal activity against tested human pathogen clinic isolates. Keywords : Hawthorn ( Creatagus monogyna ), Antimicrobial activity, Antioxidant Activity