Effects of Obesity on Heart Rate Variability in Continuous Ambulatory Peritoneal Dialysis Patients

Abstract

Both obesity and chronic kidney disease (CKD) replaced with continuous ambulatory peritoneal dialysis (CAPD) have been known as the cause of cardiac autonomic dysfunction (CAD) but there has been no study on these both conditions affecting the CAD. Thus, the purpose of study is the effects of obesity on heart rate variability (HRV) in CKD replaced with CAPD patients. There are 77 Thai subjects, categorized from their body mass index (BMI) as; normal health (NH) group, CAPD normal (CN) group, and CAPD obese (CO) group. As the results, comparing between CO and CN groups, found that the higher increase of sympathetic nervous system (SNS) of CO group has been shown by the elevation of systolic blood pressure (SBP) and heart rate (HR) compared to the CN group. Thus, the CAPD patients with obesity have been apparently shown that they have more CAD than CAPD patients with normal body weight. When the data were analyzed for correlation, the results showed that natural logarithm of high frequency (lnHF) is inversely related to triglyceride (TG) level with r = −0.553, p = 0.014, whereas, natural logarithm of low frequency (lnLF) is directly related to TG level with r = 0.489, p = 0.033. Consequently, it can be proposed that TG level may be an indicator for CAD in CAPD obese patients.