Bivariate Stochastic Modelling of Glucose and Insulin Regulatory System among Type -2 Diabetes Mellitus Patients

K. Paidipati, Tirupathi Rao Padi
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Abstract

In this paper, a bivariate stochastic model for glucose and insulin regulatory system is developed. Difference Differential equations are derived from the processes of arrival and consumption of glucose molecules and insulin granules in blood plasma. Probability generating functions and linear differential equations are obtained, through which statistical measures on glucose and insulin levels are derived. Numerical illustrations are provided with suitable sensitivity analysis. Model behaviour is analyzed while using the derived measures. Indicators on health care and management of Type-2 Diabetes can be obtained with this study.
2型糖尿病患者葡萄糖和胰岛素调节系统的双变量随机模型
本文建立了葡萄糖和胰岛素调节系统的双变量随机模型。根据血浆中葡萄糖分子和胰岛素颗粒的到达和消耗过程,导出了差分微分方程。得到了概率生成函数和线性微分方程,由此导出了葡萄糖和胰岛素水平的统计度量。给出了适当的灵敏度分析的数值实例。在使用衍生度量时分析了模型行为。通过本研究可以获得2型糖尿病的保健和管理指标。
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