Villoglandular Adenocarcinoma of Urethra with Negative CK7 Marker: Rare Disease in Atypical Location

Abstract

losartan, furosemide, atenolol, spironolactone, acetylsalicylic acid, folic acid, methotrexate and prednisone. At the physical exame, presented an exophytic and friable vegetative lesion that projected through the urethral meatus. A biopsy of the urethral lesion through transurethral resection was performed, as well as a tumor staging with computed tomography of the chess and abdomen, cystoscopy and magnetic resonance imaging of the pelvis. The fragments removed demonstrated in the histopathological evaluation villoglandular adenocarcinoma of urethra with superficial focal invasion of the connective tissue (pT1). A pelvic Magnetic Resonance showed a concentric and irregular urethral thickening of tumor aspect, involving the entire urethra with approximately 4.0cm in length and a maximum thickness of 1.2cm. The 2578-0395 Abstract Urethral cancer is a rare disease that affects predominantly males and the black race. The case report refers to a female patient of 75 years who had a history of dysuria and urethral pain. After an investigation with urethrocytoscopy and biopsy, a histopathological diagnosis of villograndular adenocarcinoma was identified. The immunohistochemical study identified the presence of beta-catenin and the absence of CK7 expression. In a literary review, few cases of this particularly histological type where published about the urethra and none of them exhibited the tumor marker CK7 negative.