Thibaut Vanbaelen , Christophe Van Dijck , Jolein Laumen , Natalia Gonzalez , Irith De Baetselier , Sheeba S. Manoharan-Basil , Tessa De Block , Chris Kenyon
{"title":"Global epidemiology of antimicrobial resistance in commensal Neisseria species: A systematic review","authors":"Thibaut Vanbaelen , Christophe Van Dijck , Jolein Laumen , Natalia Gonzalez , Irith De Baetselier , Sheeba S. Manoharan-Basil , Tessa De Block , Chris Kenyon","doi":"10.1016/j.ijmm.2022.151551","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Commensal <em>Neisseria</em> species (spp). represent an important reservoir of antimicrobial resistance genes for pathogenic <em>Neisseria</em> spp. In this systematic review, we aimed to assess the antimicrobial susceptibility of commensal <em>Neisseria</em> spp<em>.</em> and how this has evolved over time. We also aimed to assess if commensal <em>Neisseria</em> spp. showed intrinsic resistance to four antimicrobials - penicillin, azithromycin, ceftriaxone and ciprofloxacin.</p></div><div><h3>Methods</h3><p>Pubmed and Google Scholar were searched following the PRISMA guidelines. Articles reporting MICs of commensal <em>Neisseria</em> spp. were included according to inclusion/exclusion criteria, and the quality of the articles was assessed using a pre-designed tool. Individual and summary measures of penicillin, azithromycin, ceftriaxone and ciprofloxacin MICs were collected. Additional data was sought to perform a comparison between the MICs of pathogenic and commensal <em>Neisseria</em> spp.</p></div><div><h3>Results</h3><p>A total of 15 studies met our criteria.We found no evidence of intrinsic AMR in commensal <em>Neisseria</em> spp. We did find evidence of an increasing trend in MICs of commensal <em>Neisseria</em> spp. over time for all antimicrobials assessed. These findings were similar in various countries. Eight additional studies were included to compare pathogenic and commensal <em>Neisseria</em> spp.</p></div><div><h3>Conclusion</h3><p>The MICs of commensal <em>Neisseria</em> spp. appear to be increasing in multiple countries. Surveillance of MICs in commensals could be used as an early warning system for antimicrobial resistance emergence in pathogens. Our findings underline the need for antibiotic stewardship interventions, particularly in populations with high antimicrobial consumption.</p></div>","PeriodicalId":50312,"journal":{"name":"International Journal of Medical Microbiology","volume":"312 3","pages":"Article 151551"},"PeriodicalIF":4.5000,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1438422122000042/pdfft?md5=b8ea8456cca2b1b855d2e92764c21919&pid=1-s2.0-S1438422122000042-main.pdf","citationCount":"10","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Medical Microbiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1438422122000042","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 10
Abstract
Background
Commensal Neisseria species (spp). represent an important reservoir of antimicrobial resistance genes for pathogenic Neisseria spp. In this systematic review, we aimed to assess the antimicrobial susceptibility of commensal Neisseria spp. and how this has evolved over time. We also aimed to assess if commensal Neisseria spp. showed intrinsic resistance to four antimicrobials - penicillin, azithromycin, ceftriaxone and ciprofloxacin.
Methods
Pubmed and Google Scholar were searched following the PRISMA guidelines. Articles reporting MICs of commensal Neisseria spp. were included according to inclusion/exclusion criteria, and the quality of the articles was assessed using a pre-designed tool. Individual and summary measures of penicillin, azithromycin, ceftriaxone and ciprofloxacin MICs were collected. Additional data was sought to perform a comparison between the MICs of pathogenic and commensal Neisseria spp.
Results
A total of 15 studies met our criteria.We found no evidence of intrinsic AMR in commensal Neisseria spp. We did find evidence of an increasing trend in MICs of commensal Neisseria spp. over time for all antimicrobials assessed. These findings were similar in various countries. Eight additional studies were included to compare pathogenic and commensal Neisseria spp.
Conclusion
The MICs of commensal Neisseria spp. appear to be increasing in multiple countries. Surveillance of MICs in commensals could be used as an early warning system for antimicrobial resistance emergence in pathogens. Our findings underline the need for antibiotic stewardship interventions, particularly in populations with high antimicrobial consumption.
期刊介绍：
Pathogen genome sequencing projects have provided a wealth of data that need to be set in context to pathogenicity and the outcome of infections. In addition, the interplay between a pathogen and its host cell has become increasingly important to understand and interfere with diseases caused by microbial pathogens. IJMM meets these needs by focussing on genome and proteome analyses, studies dealing with the molecular mechanisms of pathogenicity and the evolution of pathogenic agents, the interactions between pathogens and host cells ("cellular microbiology"), and molecular epidemiology. To help the reader keeping up with the rapidly evolving new findings in the field of medical microbiology, IJMM publishes original articles, case studies and topical, state-of-the-art mini-reviews in a well balanced fashion. All articles are strictly peer-reviewed. Important topics are reinforced by 2 special issues per year dedicated to a particular theme. Finally, at irregular intervals, current opinions on recent or future developments in medical microbiology are presented in an editorial section.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
