Wound Healing Potential/Activity of Polyherbal Ointment Containing Salvadora persica, Azadirachta indica and Calendula officinalis Extracts: An Experimental Study

Hina Imran, A. Rehman, Tehmina Sohail, S. Shaukat, Ayesha Khokar
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引用次数: 1

Abstract

 The present study explore the wound healing potential of a novel herbal ointment formulation, fast wound healing ointment (FWHO) composed of 10% w/w crude ethanolic extracts of Salvadora persica (sticks), Azadirachta indica (leaves) and Calendula officinalis (whole plant) on excision wound model in albino rats. The FWHO was applied topically once daily on the wound to evaluate the rate of contraction and period of epithelialization in rats. Complete contraction and epithelialization of wound was observed at 19 day (P<0.0005) in test group animals compared with standard (polyfax skin ointment) at 23 day (P<0.0005) and control group (blank petroleum jelly) at 29 day respectively. It was observed that 10% FWHO has potent wound healing capability as evidenced by decrease in the period of epithelialization and increase in the rate of wound contraction in test group as compared to the standard and control groups. The test group illustrates 34.4%, while the standard group shows 20.6% decrease in the time of epithelialization as compare to control group. The study revealed that test ointment (10% FWHO) has a potential to promote wound healing by accelerating the rate of epithelialization and scar formation as compare to standard (polyfax skin ointment) and control (blank petroleum jelly) groups.
丹参、印楝和金盏菊提取物复方药膏创面愈合电位/活性的实验研究
本研究探讨了一种新型中药软膏配方——由10% w/w的木苁蓉(枝)、印楝(叶)和金盏花(整株)粗乙醇提取物组成的快速创面愈合软膏(FWHO)在白化大鼠切除创面模型上的愈合潜力。FWHO每日1次局部涂于创面,观察大鼠的收缩率和上皮化时间。试验组动物创面在第19天完全收缩和上皮化(P<0.0005),与标准组(多法皮肤软膏)创面在第23天(P<0.0005)和对照组(空白凡士林)创面在第29天(P<0.0005)比较。结果表明,与标准组和对照组相比,试验组皮肤上皮化时间缩短,创面收缩率增加,10% FWHO具有较强的创面愈合能力。试验组上皮化时间比对照组减少34.4%,标准组上皮化时间比对照组减少20.6%。研究表明,与标准组(多法克斯皮肤软膏)和对照组(空白凡士林)相比,试验软膏(10% FWHO)有可能通过加速上皮化和疤痕形成的速度来促进伤口愈合。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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