Comparative Study Between The Efficacy of Ozone Gel and Hyaluronic Acid on Bone Healing After Enucleation of Mandibular Odontogenic Cysts

Abstract

Aim: The aim of this study was to evaluate the clinical and radiographic effect of both Ozone gel and Hyaluronic acid after enucleation of mandibular odontogenic cysts. Subjects and methods: 24 patients complained of an odontogenic cystic lesion in mandible classified into three groups, Group I (Ozone group): Included 8 patients with odontogenic cysts treated by Enucleation followed by Ozone gel application in the surgical cavity. Group II (HA group): Included 8 patients with odontogenic cysts treated by Enucleation followed by Hyaluronic acid application in the surgical cavity. Group III ( Control group): Included 8 patients with odontogenic cysts treated by Enucleation only. Postoperative one-month panoramic view, 3, 6 cone-beam C.T as the radiographic follow-up. Facial edema, pain, and trismus were the clinical parameters at 1,3 and 7 days. Results: The study showed a significant increase in the bone density of both group I (ozone), II (Hyaluronic acid) than the control group comparing the percentage of bone density to the contralateral bone, it was for group I (Ozone group) 45.8%, 69% at follow up of 3,6, months. In group II ( HA ) it was for 51.9%, 72% at follow up of 3, 6, months. It was for group III (control group) 32.6%, 56.1% at follow up of 3, 6, 9 months as there was high statistical significance between-group I, II in comparing with the group I with P-value = 0.04,0.05. .Conclusion: Both ozone gel and Hyaluronic acid can be considered to enhance bone regeneration after cystic enucleation due to their specific antimicrobial, anti-inflammatory properties, and increasing angiogenesis in the post-surgical cavities. Over 90% of maxillofacial cysts are odontogenic in origin that is considered to be the most common group lesion that affects the maxilla and mandible. Many odontogenic cysts are asymptomatic and may be found accidentally during radiographic examination. Kramer (1) defined the cyst as a pathological cavity containing fluid, semifluid or gaseous material. In the maxillofacial area, odontogenic cysts are lined by epithelium except for solitary bone cysts and aneurysmal bone cysts (2)