{"title":"Effects of maternal exposure to trioxane on postnatal development in rats.","authors":"K Sitarek, B Barański","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Female rats were given by gavage every other day from days 2 to 20 of gestation an aqueous solution of trioxane at daily doses equal to 0.025; 0.075 and 0.15 LD50 (0.19: 0.58 and 1.16 g/kg). Maternal exposure to trioxane at the highest dose resulted in death of most neonates a few days after birth. Viability and postnatal growth of the offspring of dams that were given 0.19 and 0.58 g/kg were not affected. Transitional depression of exploratory locomotor activity in female offspring and a decrease of active avoidance acquisition were observed in adult male and female offspring from the 0.58 g/kg group, whereas a dose of 0.19 g trioxane /kg did not affect the behavioral performance of progeny.</p>","PeriodicalId":77768,"journal":{"name":"Polish journal of occupational medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Polish journal of occupational medicine","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Female rats were given by gavage every other day from days 2 to 20 of gestation an aqueous solution of trioxane at daily doses equal to 0.025; 0.075 and 0.15 LD50 (0.19: 0.58 and 1.16 g/kg). Maternal exposure to trioxane at the highest dose resulted in death of most neonates a few days after birth. Viability and postnatal growth of the offspring of dams that were given 0.19 and 0.58 g/kg were not affected. Transitional depression of exploratory locomotor activity in female offspring and a decrease of active avoidance acquisition were observed in adult male and female offspring from the 0.58 g/kg group, whereas a dose of 0.19 g trioxane /kg did not affect the behavioral performance of progeny.