[Proteolytic and collagenolytic activities of experimental methylcholanthrene-induced fibrosarcoma].

Abstract

Rat fibrosarcoma induced by methylcholanthrene exhibited proteolytic activity against type I collagen at acidic range of pH values. This activity was not only collagen-specific as it was able to cause hemoglobin degradation to low-molecular products. No collagenolytic activity was found near physiological values pH.