Effects of sodium taurocholate and sodium dehydrocholate on bile flow, lipid and bilirubin secretion in sheep.

Acta physiologica Polonica Pub Date : 1990-11-01
R Bobowiec, T Studziński, M Sikorska
{"title":"Effects of sodium taurocholate and sodium dehydrocholate on bile flow, lipid and bilirubin secretion in sheep.","authors":"R Bobowiec,&nbsp;T Studziński,&nbsp;M Sikorska","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The investigation was performed on 8 sheep with implanted catheters in the common bile duct and in the cystic duct. Sodium taurocholate and sodium dehydrocholate were infused into the jugular vein at the rate of 50 mumol/min for 20 min. Directly after the termination of the sodium taurocholate infusion, the volume of the secreted bile increased from 8.4-9 microliters.kg-1.min-1 to the highest mean value of 17.8 microliters.kg-1, min-1, with a simultaneous increase in the concentration of cholates from 1.71 mmol/l to 4.82 mmol/l and bilirubin from 271.1 mumol/l to 461.7 mumol/l. The concentration of cholesterol and phospholipids in the bile also increased, but did not reach statistically significant values. The infusion of sodium dehydrocholate caused an increase in the bile secretion to the highest mean value of 20.59 microliters.kg-1.min-1 with a simultaneous decrease in the concentration of bilirubin to 148.75 mumol/l, cholesterol to 233.0 micrograms/ml, phospholipids to 56.11 micrograms/ml and cholate to 1.0 mmol/l. The results show that biliary secretion of phospholipids, cholesterol and bilirubin is dependent on the secretion of sodium taurocholate rather than on dehydrocholic acid.</p>","PeriodicalId":7158,"journal":{"name":"Acta physiologica Polonica","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1990-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta physiologica Polonica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

The investigation was performed on 8 sheep with implanted catheters in the common bile duct and in the cystic duct. Sodium taurocholate and sodium dehydrocholate were infused into the jugular vein at the rate of 50 mumol/min for 20 min. Directly after the termination of the sodium taurocholate infusion, the volume of the secreted bile increased from 8.4-9 microliters.kg-1.min-1 to the highest mean value of 17.8 microliters.kg-1, min-1, with a simultaneous increase in the concentration of cholates from 1.71 mmol/l to 4.82 mmol/l and bilirubin from 271.1 mumol/l to 461.7 mumol/l. The concentration of cholesterol and phospholipids in the bile also increased, but did not reach statistically significant values. The infusion of sodium dehydrocholate caused an increase in the bile secretion to the highest mean value of 20.59 microliters.kg-1.min-1 with a simultaneous decrease in the concentration of bilirubin to 148.75 mumol/l, cholesterol to 233.0 micrograms/ml, phospholipids to 56.11 micrograms/ml and cholate to 1.0 mmol/l. The results show that biliary secretion of phospholipids, cholesterol and bilirubin is dependent on the secretion of sodium taurocholate rather than on dehydrocholic acid.

牛磺胆酸钠和脱氢胆酸钠对绵羊胆汁流量、脂质和胆红素分泌的影响。
对8只羊在胆总管和胆囊管内植入导管进行了研究。将牛磺胆酸钠和脱氢胆酸钠以50 μ mol/min的速度注入颈静脉,持续20 min。终止牛磺胆酸钠输注后,胆汁分泌量由8.4-9微升/ kg-1增加。最小-1至最高平均值17.8微升。Kg-1, min-1,同时胆固醇浓度从1.71 mmol/l增加到4.82 mmol/l,胆红素从271.1 mumol/l增加到461.7 mumol/l。胆汁中胆固醇和磷脂的浓度也增加了,但没有达到统计学意义的值。输注脱氢胆酸钠引起胆汁分泌增加,最高平均值为20.59微升。kg-1。Min-1,同时胆红素浓度降至148.75 μ mol/l,胆固醇降至233.0微克/ml,磷脂降至56.11微克/ml,胆酸盐降至1.0 mmol/l。结果表明,胆磷脂、胆固醇和胆红素的分泌依赖于牛磺胆酸钠的分泌,而不依赖于脱氢胆酸。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信