The influence of pinealectomy and single dose of melatonin administered at different times of day on serum T3 and T4 concentrations in rats.

Acta physiologica Polonica Pub Date : 1990-11-01
B Kniazewski, Z Ostrowska, K Zwirska-Korczala, B Buntner
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Abstract

The influence of pinealectomy and melatonin administration on the levels of total T3 and T4 plasma levels were determined by RIA method. The results of hormonal measurements were evaluated by means of Student's t-test, and the diurnal rhythm by cosinor method. It has been established that pinealectomy disturbs the T3 diurnal rhythm and caused marked changes in T4 levels during the 24 hours. Exogenous melatonin does not influence the thyroid function during the light phase. During the dark phase, however, its inhibitory effect is prevalent in pinealectomized rats, and the stimulating in sham operated rats.

松果体切除和不同时间单剂量褪黑素对大鼠血清T3和T4浓度的影响。
采用RIA法测定松果体切除术和褪黑素治疗对血浆总T3和T4水平的影响。激素测量结果采用学生t检验,昼夜节律采用余弦法。已经证实,松果体切除术扰乱了T3昼夜节律,并引起24小时内T4水平的明显变化。外源性褪黑素在光照期不影响甲状腺功能。而在黑暗期,其抑制作用在去松果体大鼠中普遍存在,刺激作用在假手术大鼠中普遍存在。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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