Motor nucleus of the V-th nerve and the control of breathing. Breuer-Hering reflexes and apneustic breathing.

Acta physiologica Polonica Pub Date : 1990-11-01
H Gromysz, A W Karczewski, U Jernajczyk
{"title":"Motor nucleus of the V-th nerve and the control of breathing. Breuer-Hering reflexes and apneustic breathing.","authors":"H Gromysz,&nbsp;A W Karczewski,&nbsp;U Jernajczyk","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Earlier studies from this department have demonstrated that neurones of the V-th nerve motor nucleus (NVmt) have oligosynaptic, inhibitory output to the inspiratory motoneurone themselves under the influence of a polysynaptic input from vagal afferents. To check the hypothesis that NVmt is a part of the pneumotaxic mechanism, we studied the effects of pharmacological microblockade of the NVmt on Breuer-Hering reflexes in halothane-anesthetized, paralyzed and artificially ventilated rabbits. Activities of NVmt neurones and phrenic nerve firing were recorded. Acid-base balance was controlled and histologic examinations were routinely performed. Expiratory activities were regulatory found in NVmt. Its blockade elicited a typical apneustic breathing. During the blockade the Breuer-Hering reflexes gave \"paradoxical\" effects: an increase in central respiratory frequency following inflation, inspiratory apneusis in response to deflation. We conclude that the NVmt is an important component of the pneumotaxic mechanism or even the anatomical substrate of the pneumotaxic \"centre\".</p>","PeriodicalId":7158,"journal":{"name":"Acta physiologica Polonica","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1990-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta physiologica Polonica","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Earlier studies from this department have demonstrated that neurones of the V-th nerve motor nucleus (NVmt) have oligosynaptic, inhibitory output to the inspiratory motoneurone themselves under the influence of a polysynaptic input from vagal afferents. To check the hypothesis that NVmt is a part of the pneumotaxic mechanism, we studied the effects of pharmacological microblockade of the NVmt on Breuer-Hering reflexes in halothane-anesthetized, paralyzed and artificially ventilated rabbits. Activities of NVmt neurones and phrenic nerve firing were recorded. Acid-base balance was controlled and histologic examinations were routinely performed. Expiratory activities were regulatory found in NVmt. Its blockade elicited a typical apneustic breathing. During the blockade the Breuer-Hering reflexes gave "paradoxical" effects: an increase in central respiratory frequency following inflation, inspiratory apneusis in response to deflation. We conclude that the NVmt is an important component of the pneumotaxic mechanism or even the anatomical substrate of the pneumotaxic "centre".

第五神经的运动核和呼吸的控制。布鲁尔-赫令反射和窒息性呼吸。
该系的早期研究表明,在迷走神经传入的多突触输入的影响下,第v神经运动核(NVmt)的神经元对吸气运动神经元本身具有寡突触的抑制性输出。为了验证NVmt参与肺致死机制的假设,我们研究了NVmt药理微阻断对氟烷麻醉、麻痹和人工通气家兔布鲁尔-赫令反射的影响。记录NVmt神经元活动和膈神经放电。控制酸碱平衡,常规进行组织学检查。NVmt的呼气活动具有调节作用。它的封锁引起了典型的窒息性呼吸。在封锁期间,布鲁尔-赫林反射产生了“矛盾”的效果:通货膨胀后中央呼吸频率增加,通货紧缩时吸气性呼吸暂停。我们得出结论,NVmt是肺滑行机制的重要组成部分,甚至是肺滑行“中心”的解剖基底。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信