Effect of chronic ethanol treatment and the abstinence period on the ethanol elimination by isolated rat liver lesioned by carbon tetrachloride.

Acta physiologica Polonica Pub Date : 1990-11-01
G Rajtar, Z Kleinrok
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Abstract

The study was carried out on perfused livers isolated from rats receiving ethanol (EtOH) as their only drinking fluid for the period of 4 weeks. Twelve, 24, 72 and 120 hours after EtOH withdrawal the livers were isolated and perfused with 100 ml of perfusion mixture with addition of EtOH (0.2% final concentration). After 12 hours of EtOH withdrawal acceleration of the EtOH elimination from perfusate was observed. It returned to the control level after 24 hours, but after 72 and 120 hours of abstinence the rate of EtOH elimination from perfusate was found to diminish. CCl4 injected to the rats in doses of 2 and 5 mmoles/kg once a week for the period of 4 or 8 weeks, resulted in decreased EtOH elimination from the perfusate. In the EtOH-drinking group previously treated with CCl4 we found that irrespective of the time of EtOH withdrawal, EtOH elimination did not differ from that in the respective CCl4 treated group, only 12 hours after its withdrawal EtOH elimination was decreased in livers injured with CCl4 in dose of 5 mmoles/kg.

慢性乙醇治疗及戒断期对四氯化碳损伤大鼠离体肝脏乙醇清除的影响。
本研究以乙醇(EtOH)为唯一饮用液体的大鼠分离的灌注肝脏进行,为期4周。取EtOH后12、24、72和120 h,分离肝脏,加入EtOH(0.2%终浓度)的灌注液100 ml灌注。停用EtOH 12小时后,观察到灌注液中EtOH的消除加速。24小时后恢复到对照水平,但在72和120小时后,灌注液中EtOH的消除率下降。CCl4以2和5 mmol /kg的剂量注射大鼠,每周1次,连续注射4周或8周,可减少灌注液中EtOH的消除。在先前用CCl4治疗的饮用EtOH组中,我们发现,无论停药时间如何,EtOH的消除与相应的CCl4治疗组没有差异,在停药后仅12小时,CCl4剂量为5毫摩尔/千克时损伤肝脏的EtOH消除就减少了。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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