Alanine and aspartate aminotransferase activities in muscles of diabetic rats.

Acta physiologica Polonica Pub Date : 1990-01-01
J Rutkiewicz, M Górska, J Górski
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Abstract

Activities of alanine and aspartate aminotransferase in different muscle types and in the liver of streptozotocin diabetic rats were studied 1,2 and 3 days after administering of streptozotocin. It was shown that the activity of both enzymes was elevated in the "white" layer of the vastus lateralis, in the liver and in the heart, whereas it remained unchanged in the "red" layer of the same muscle, in the soleus and the diaphragm. It is concluded that the effect of acute insulin deficiency on the aminotransferase activity in skeletal muscles depends on the muscle fiber composition and does not appear in muscles with a high oxidative potential. These results indicate that muscle fiber composition should be taken into account when evaluating the role of insulin in amino acid metabolism in the muscle.

糖尿病大鼠肌肉中丙氨酸和天冬氨酸转氨酶的活性。
应用链脲佐菌素后1、2、3 d,观察糖尿病大鼠不同肌肉类型和肝脏中丙氨酸和天冬氨酸转氨酶的活性。结果表明,这两种酶的活性在股外侧肌的“白色”层、肝脏和心脏中都有所升高,而在同一块肌肉的“红色”层、比目鱼肌和横膈膜中则保持不变。由此可见,急性胰岛素缺乏对骨骼肌转氨酶活性的影响与肌纤维组成有关,并不出现在氧化电位高的肌肉中。这些结果表明,在评估胰岛素在肌肉氨基酸代谢中的作用时,应考虑肌纤维组成。
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