Interaction between the sarcoplasmic reticulum and mitochondria in the control of contractile calcium in guinea-pig atria--does it exist?

Acta physiologica Polonica Pub Date : 1990-01-01
A Prokopczuk
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Abstract

The inhibitory action of caffeine on calcium (Ca2+) release from the sarcoplasmic reticulum (SR) and interference with mitochondrial (Ca2+) fluxes by a mitochondrial uncoupler protonfore CCCP were utilized to define a calcium pool responsible for potentiation of post-rest twitch tension in guinea-pig atria. The Ca2+ fluxes were assessed by means of 45Ca2+. Caffeine and CCCP when applied separately did not affect post-rat 45Ca2+ content. Yet, when they were applied together it was markedly reduced to the resting level. It is concluded that a possible source of contractile Ca2+ may be located in mitochondria and an eventual shift of Ca2+ between mitochondria and the SR seems to be a plausible assumption.

肌浆网和线粒体在控制豚鼠心房收缩钙中的相互作用——是否存在?
咖啡因对肌浆网(SR)钙(Ca2+)释放的抑制作用和线粒体解偶联蛋白CCCP对线粒体(Ca2+)通量的干扰作用被用来确定一个钙池,该钙池负责增强豚鼠心房休息后抽搐张力。通过45Ca2+测定Ca2+通量。单独施用咖啡因和CCCP时,不影响大鼠后45Ca2+含量。然而,当它们一起使用时,它显着降低到静息水平。这是结论,一个可能的来源的收缩Ca2+可能位于线粒体和Ca2+的最终转移之间的线粒体和SR似乎是一个合理的假设。
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