Effect of “Ying Wei Fang” on Vascular Endothelial Function in Patients with Different Syndromes of Type 2 Diabetes Mellitus

2021 International Conference on Computer Engineering and Artificial Intelligence (ICCEAI) Pub Date : 2021-08-01 DOI:10.1109/ICCEAI52939.2021.00095

Li Ruiyu, Li Yue, L. Xing, Li Meng

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Abstract

Objective: To investigate the effects of “Yingwei Fang” on nitric oxide synthase (eNOS), endothelin-converting enzyme (ECE) and homocysteine (Hey) in patients with type 2 diabetes mellitus. Methods: 39 cases of type 2 diabetes mellitus with different syndromes were observed, including 14 cases of Yin deficiency heat, 10 cases of Qi and Yin deficiency and 15 cases of Yin and Yang deficiency. All patients took “Yingwei Fang” capsules orally, 5 capsules per time, 3 times a day. At the same time, they were combined with conventional treatment such as dialectical TCM dialectical theory of treatment and hypoglycemia. The changes of eNOS, ECE and Hcy were measured after 150 days of treatment and compared with those before treatment. RESULTs: After treatment, there were changes in $e$NOS, ECE and Hcy in patients with Yin deficiency, Qi and Yin deficiency and Yin and Yang deficiency, among which eNOS, ECE and Hcy were significantly improved (P<0.05). ECE and Hcy were significantly improved in both Qi and Yin deficiency (P<0.01). Conclusion: “Yingwei Fang” can significantly improve vascular endothelial function in patients with type 2 diabetes.

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应胃方对2型糖尿病不同证型患者血管内皮功能的影响

目的:探讨应味方对2型糖尿病患者一氧化氮合酶(eNOS)、内皮素转换酶(ECE)及同型半胱氨酸(Hey)的影响。方法:对39例不同证型2型糖尿病患者进行临床观察，其中阴虚热型14例，气阴虚型10例，阴阳虚型15例。患者均口服“应味方”胶囊，每次5粒，每日3次。同时结合辨证中医辨证论治及降糖等常规治疗方法。治疗150 d后测定eNOS、ECE、Hcy的变化，并与治疗前比较。结果:治疗后阴虚、气阴虚、阴阳虚患者的$e$NOS、ECE、Hcy均有变化，其中eNOS、ECE、Hcy明显改善(P<0.05)。气阴虚组ECE和Hcy均显著提高(P<0.01)。结论:应胃方能明显改善2型糖尿病患者血管内皮功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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2021 International Conference on Computer Engineering and Artificial Intelligence (ICCEAI)

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