{"title":"Development of biodegradable PLGA microspheres for use as ultrasound contrast agents","authors":"D. El-Sherif, M. Wheatley","doi":"10.1109/NEBC.2001.924712","DOIUrl":null,"url":null,"abstract":"The authors have developed a method for producing hollow/porous poly (lactide co-glycolide) (PLGA) microcapsules with a mean size of 1 /spl mu/m by a modified double emulsion, solvent evaporation technique. Besides being biocompatible and biodegradable, these microspheres exhibit acoustic enhancements that make them useful as contrast agents for diagnostic imaging using ultrasound. Moreover, they are very stable and give a prolonged acoustic enhancement, as compared to other ultrasound contrast agents.","PeriodicalId":269364,"journal":{"name":"Proceedings of the IEEE 27th Annual Northeast Bioengineering Conference (Cat. No.01CH37201)","volume":"35 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2001-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the IEEE 27th Annual Northeast Bioengineering Conference (Cat. No.01CH37201)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/NEBC.2001.924712","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
The authors have developed a method for producing hollow/porous poly (lactide co-glycolide) (PLGA) microcapsules with a mean size of 1 /spl mu/m by a modified double emulsion, solvent evaporation technique. Besides being biocompatible and biodegradable, these microspheres exhibit acoustic enhancements that make them useful as contrast agents for diagnostic imaging using ultrasound. Moreover, they are very stable and give a prolonged acoustic enhancement, as compared to other ultrasound contrast agents.