ANALYSIS AND EVALUATION OF BLOOD PLASMA PROTEOMIC PROFILE VIOLATIONS DUE TO THE INCREASED CONCENTRATION OF FLUORIDE ION IN CHILDREN’S URINE

Здоровье населения и среда обитания - ЗНиСО Pub Date : 2019-07-01 DOI:10.35627/2219-5238/2019-316-7-23-26

N. Zaitseva, M. Zemlianova, N. Bulatova, J. V. Koldibekova

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引用次数: 5

Abstract

We evaluated the air quality by the content of fluorine-containing compounds according to monitoring studies, chemical and analytical determination of fluoride ion in urine and performed proteomic analysis of blood plasma in children of the observation and comparison group. The increased content of fluoride ion in the urine was found in children of the observation group relative to the same indicator in children of the comparison group and the reference level in conditions of poor air quality for the hydrofluoride content due to the economic activity of aluminum production facilities. The concentration of fluoride ion in the urine is justified as a marker of inhalation exposure. A comparative analysis revealed the presence of significant differences in the relative volume of protein spots. Mass spectra were obtained that contain information about the peptides included in the composition of the studied protein set and the genes encoding identifiable proteins were established.

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儿童尿液中氟离子浓度升高对血浆蛋白质组谱影响的分析与评价

我们根据监测研究、尿液中氟离子的化学和分析测定以及观察组和对照组儿童血浆的蛋白质组学分析，通过含氟化合物的含量来评价空气质量。观察组儿童尿液中氟离子含量相对于对照组儿童的相同指标和由于铝生产设施的经济活动导致的氢氟化物含量在空气质量较差的条件下的参考水平有所增加。尿液中氟离子的浓度作为吸入暴露的标志是合理的。比较分析显示，蛋白质斑点的相对体积存在显著差异。获得的质谱包含了所研究的蛋白质组合中包含的肽的信息，并建立了编码可识别蛋白质的基因。

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Здоровье населения и среда обитания - ЗНиСО

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