Andrew J. Patterson MD, PhD, Nathan Pearl, Christine Chang
{"title":"Impact of phosphodiesterase 4D on cardiac β2 adrenergic receptor signaling","authors":"Andrew J. Patterson MD, PhD, Nathan Pearl, Christine Chang","doi":"10.1053/j.sane.2006.11.002","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>Cyclic adenosine monophosphate (cAMP) is an important intracellular second messenger whose levels are tightly regulated within intracellular subdomains. Generation, detection, and degradation of cAMP is influenced by signaling complexes localized to specific regions of the cell by scaffolding proteins<span>, such as muscle A kinase-anchoring protein (mAKAP). The distribution of cAMP within myocytes differs after β1 adrenergic receptor (β1AR) activation relative to β2AR activation as a result of differences in the interaction of these </span></span>receptor subtypes with signaling complexes. </span>β1AR stimulation<span> generates a global increase in cAMP, whereas β2AR stimulation elicits a cAMP increase only within restricted areas of the cell. Phosphodiesterase 4D (PDE4D) plays an important role in this process.</span></p></div>","PeriodicalId":82686,"journal":{"name":"Seminars in anesthesia","volume":"26 1","pages":"Pages 22-27"},"PeriodicalIF":0.0000,"publicationDate":"2007-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1053/j.sane.2006.11.002","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Seminars in anesthesia","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0277032607000037","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Cyclic adenosine monophosphate (cAMP) is an important intracellular second messenger whose levels are tightly regulated within intracellular subdomains. Generation, detection, and degradation of cAMP is influenced by signaling complexes localized to specific regions of the cell by scaffolding proteins, such as muscle A kinase-anchoring protein (mAKAP). The distribution of cAMP within myocytes differs after β1 adrenergic receptor (β1AR) activation relative to β2AR activation as a result of differences in the interaction of these receptor subtypes with signaling complexes. β1AR stimulation generates a global increase in cAMP, whereas β2AR stimulation elicits a cAMP increase only within restricted areas of the cell. Phosphodiesterase 4D (PDE4D) plays an important role in this process.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
