Intraperitoneal application of fibrinogen gluing in the rat for adhesions prophylaxis.

Progress in pediatric surgery Pub Date : 1990-01-01 DOI:10.1007/978-3-642-87707-0_9

J L Koltai, A Gerhard

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引用次数: 9

Abstract

The suitability of fibrinogen gluing for prophylaxis of intraperitoneal adhesions was investigated experimentally. Small bowel slings, traumatized previously, were covered by a layer of fibrinogen 2-3 mm thick to see whether formation of adhesions could be prevented. In the experiments 50 rats of both sexes were observed over 21 days. Following mechanical traumatization of the terminal ileum the visceral peritoneum was coated with fibrinogen, whereas animals of the control group did not receive fibrinogen coating. Macroscopic and microscopic findings after 1, 3, 7, 14 and 21 days yielded the following results: 1. Fibrinogen dissolution and resorption occurred for 3-14 days following operation. 2. On autopsy, all animals of the control group showed massive, extended adhesions; two of the controls died on the 6th postoperative day from peritonitis. 3. None of the treated animals exhibited extended adhesions. 4. Histological examinations revealed regeneration of the injured serosa and healing of the bowel wall below the fibrinogen coating. 5. Fibrinogen applied to intact peritoneal serosa (without injury) is entirely resorbed without formation of adhesions.

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纤维蛋白原胶凝在大鼠腹腔内预防粘连的应用。

实验探讨纤维蛋白原粘接预防腹腔粘连的适用性。先前损伤的小肠吊带被一层2-3毫米厚的纤维蛋白原覆盖，以观察是否可以防止粘连的形成。实验对50只雌雄大鼠进行了21天的观察。回肠末端机械损伤后，内脏腹膜涂覆纤维蛋白原，而对照组动物不涂覆纤维蛋白原。1、3、7、14、21天后的宏观和微观观察结果如下:术后3 ~ 14 d出现纤维蛋白原溶解和再吸收。2. 尸检时，对照组所有动物均出现大量延伸粘连;2例对照组于术后第6天死于腹膜炎。3.没有治疗过的动物表现出延长的粘连。4. 组织学检查显示损伤的浆膜再生和纤维蛋白原包被下的肠壁愈合。5. 纤维蛋白原应用于完整的腹膜浆膜(无损伤)被完全吸收而不形成粘连。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Progress in pediatric surgery

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