[Experimental research on the toxicity of pharmapentoxifylline (I)].

Abstract

Results from the study on acute, subacute and chronic toxicity of the therapeutic preparation pharmapentoxiphyline (PP), produced by Pharmachem, are described. The experiments were carried out on 312 male and female white rats. According to the limiting index of LD50 with, Oral dose of (1220 mg/kg of body mass for male rats and 1050 mg/kg for female rats) and intraperitoneal PP dose of PP (230 mg/kg for female rats and 235 mg/kg for female rats) it was included into IV class of slightly toxic compounds. Doses of 100, 300 and 600 mg/kg/oral administration) and 30, 75 and 150 mg/kg (intraperitoneal administration) were used in subacute and chronic experiments. Integral, hematological and biochemical methods and parameters were applied for evaluation of the toxic effect. There was no hemato-, hepato- and nephrotoxicity after oral and intraperitoneal administration of PP in doses of 10 and 30 mg/kg for a period of 3 months. Some recommendations, which should be taken into consideration during continuous treatment with PP, are given on the basis of a complex evaluation of the results from the hematological parameters.