APPLICATION OF SEROEPIDEMIOLOGY IN THE EVALUATION OF A COMMUNITY-BASED MALARIA CONTROL PROGRAM IN PALAWAN, THE PHILIPPINES

Japanese Journal of Tropical Medicine and Hygiene Pub Date : 1999-06-15 DOI:10.2149/TMH1973.27.161

P. Tongol-Rivera, S. Kano, Elena A. Villacorte, Alldrin Darilag, E. Miguel, Mamoru Suzuki

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Abstract

Seroepidemiology has several proven applications in malaria endemic areas. In this study, it was used to assess the effectiveness of a community-based malaria control program in the focus of malaria transmission. The first serological survey was done before the implementation of a community-based malaria control program (pre-intervention), and the second one was done after 5 years of intervention in the study area. Comparison of the distribution of the indirect fluorescent antibody (IFA) titers showed a reduction in the high titer-responses after the intervention. Moreover, there was a statistically significant reduction in the geometric mean reciprocal titer (GMRT) after the intervention. These findings were suggestive of a reduction in malaria transmission resulting from the intervention. Results of a parallel parasitologic study revealed the same findings. Therefore, seroepidemiology, when used to complement the parasitologic measurement, is valuable in monitoring the effectiveness of malaria control measures.

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应用血清流行病学评价菲律宾巴拉望岛社区疟疾控制规划

血清流行病学在疟疾流行地区有若干已证实的应用。在本研究中，它被用来评估以社区为基础的疟疾控制项目在疟疾传播重点领域的有效性。第一次血清学调查是在实施社区疟疾控制规划(干预前)之前进行的，第二次血清学调查是在研究地区干预5年后进行的。间接荧光抗体(IFA)滴度分布的比较显示，干预后高滴度反应减少。此外，干预后几何平均滴度(GMRT)有统计学意义的降低。这些发现表明，干预措施减少了疟疾传播。一项平行的寄生虫学研究结果显示了同样的结果。因此，当血清流行病学用于补充寄生虫学测量时，对监测疟疾控制措施的有效性是有价值的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Japanese Journal of Tropical Medicine and Hygiene

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