Schiff Bases having A Triazole Ring Bearing a Pyridyl Moiety are Synthesised, and their Biological Activities are Studied

Zamzam Mohamad, Dawood S. Abid
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引用次数: 0

Abstract

The most frequently used organic compounds are Schiff bases. They have been demonstrated to have a broad variety of biological activities. Using a thermal method, the synthesis of a series of imine derivatives 4a-f from Amino triazole thiol (3) as starting material with six different aldehydes. Target compounds' full characteriszation was achieved using 1H and 13C- NMR, mass spectra, and FT-IR. In the 1H-NMR spectra of compounds (4a-f), an isotope with a proton signal for the CH of the azomethine group that ranged from 8 to 10.30 ppm was observed. Due to labile hydrogen bonds with nitrogen and sulfur, compound 3 exists in two tautomeric forms. Synthesis compounds' antibacterial activity was investigated against the bacteria Klebsiella, E. coli and, S. aureus
合成了含吡啶基三唑环的希夫碱,并对其生物活性进行了研究
最常用的有机化合物是席夫碱。它们已被证明具有广泛的生物活性。以氨基三唑硫醇(3)为原料,以六种不同的醛为原料,采用热法合成了一系列亚胺衍生物4a-f。利用1H和13C- NMR、质谱和FT-IR对目标化合物进行了全面表征。在化合物(4a-f)的1H-NMR谱中,观察到一种质子信号为亚甲基CH的同位素,其质子信号范围为8 ~ 10.30 ppm。由于与氮和硫的氢键不稳定,化合物3以两种互变异构形式存在。研究了合成的化合物对克雷伯氏菌、大肠杆菌和金黄色葡萄球菌的抑菌活性
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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