{"title":"Schiff Bases having A Triazole Ring Bearing a Pyridyl Moiety are Synthesised, and their Biological Activities are Studied","authors":"Zamzam Mohamad, Dawood S. Abid","doi":"10.37648/ijrmst.v16i01.002","DOIUrl":null,"url":null,"abstract":"The most frequently used organic compounds are Schiff bases. They have been demonstrated to have a broad variety of biological activities. Using a thermal method, the synthesis of a series of imine derivatives 4a-f from Amino triazole thiol (3) as starting material with six different aldehydes. Target compounds' full characteriszation was achieved using 1H and 13C- NMR, mass spectra, and FT-IR. In the 1H-NMR spectra of compounds (4a-f), an isotope with a proton signal for the CH of the azomethine group that ranged from 8 to 10.30 ppm was observed. Due to labile hydrogen bonds with nitrogen and sulfur, compound 3 exists in two tautomeric forms. Synthesis compounds' antibacterial activity was investigated against the bacteria Klebsiella, E. coli and, S. aureus","PeriodicalId":178707,"journal":{"name":"International Journal of Research in Medical Sciences and Technology","volume":"61 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Research in Medical Sciences and Technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37648/ijrmst.v16i01.002","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The most frequently used organic compounds are Schiff bases. They have been demonstrated to have a broad variety of biological activities. Using a thermal method, the synthesis of a series of imine derivatives 4a-f from Amino triazole thiol (3) as starting material with six different aldehydes. Target compounds' full characteriszation was achieved using 1H and 13C- NMR, mass spectra, and FT-IR. In the 1H-NMR spectra of compounds (4a-f), an isotope with a proton signal for the CH of the azomethine group that ranged from 8 to 10.30 ppm was observed. Due to labile hydrogen bonds with nitrogen and sulfur, compound 3 exists in two tautomeric forms. Synthesis compounds' antibacterial activity was investigated against the bacteria Klebsiella, E. coli and, S. aureus