HLA antigens in children with epilepsy.

Abstract

In accord with our results, a significantly higher occurrence of HLA-B17, B27 and A2, B27 haplotype is scrutinized in a total of epileptical children with psoriasis inheritance comparably to the occurrence rate in population (P = 0.05; P = 0.01; P = 0.001). We failed to detect HLA-B13 antigen in our 9 healthy siblings, though this finding was insignificant in our group. Mentioned findings are supporting the suggestion that also HLA-linked genetic factors associated with the type of immune responsiveness may be involved in pathogenesis of epilepsies in our patients. Nevertheless, due to the restricted number of examinations provided, our results are only of tracing value in presuming possible importance of HLA antigenic monitoring in postinflammatory epilepsy, so they cannot give us a satisfactory response. In the next future, it would be suitable to perform these examinations on far larger group of patients including the II. class HLA antigenic assessment.