Activation of FAK promotes ERK-mediated osteogenesis for tensile force-subjected periodontal ligament cell

Abstract

The exact mechanism of translate mechanical signals of the focal adhesion kinase (FAK) into osteoblast differentiation power. PDL cells and MG63 cells were under-100 kPa for different periods. The tension force of focal adhesion kinase (FAK) phosphorylation increases rapidly and upregulation of osteogenic protein expression in periodontal ligament cells, but not in MG63 cells with FAK antisense oligonucleotides decreased ALP and Osteocalcin (OC) secretion in cells transfected with PDL. These findings suggest that the tension of the activation of the FAK pathway in periodontal ligament cells, and regulate immune cytokines and regulation of bone morphogenetic protein.