Malignant Peripheral Nerve Sheath Tumor with Loss of SMARCB1 and Diffuse S1000 Expression Arising in a Trigeminal Nerve Schwannoma

Abstract

Malignant peripheral nerve sheath tumors (MPNSTs) are rare sarcomas of the nerve sheath that infrequently involve the head and neck region. The few reports of MPNSTs arising from benign schwannoma precursors typically exhibit epithelioid morphology.